A key factor in building heat gain and loss may be the infiltration rate, or the rate at which outdoor air is exchanged with conditioned interior air through the envelope. This spreadsheet tool outlines a set of simplified equations aimed at converting typical, real world infiltration measurements into metrics that can be input into EnergyPlus.
In using methods outlined in the document Infiltration Modeling Guidelines for Commercial Building Energy Analysis by the Pacific Northwest National Laboratory, we were able to convert common metrics of I75 and ACH50, into ones that could be conveniently input into an Energy Plus Model (Idesign and ACHnat).
NOTE: At this time, this calculation tool does not take into account infiltration from stack pressure, only horizontal wind pressure.